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Identification of deactivation procedure for Trilaciclib
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The Indian health-care facilities (HCFs) made some guidelines related to cytotoxic drugs so called cytotoxic policy for patient safety and health-care worker safety, and environmental monitoring program as per the available international guidelines. Trilaciclib is indicated for the treatment of patients with multiple myeloma and chemically it is a tetra peptide epoxy ketone and an analog of epoxomicin. Analytical method for the detection of Deactivating agent and concentration play an impartment role in the pharmaceuticals especially with cytotoxic molecules after completion of manufacturing and testing is mandatory to follow the safety protocol to dispose those materials. The present invention provides to identify the suitable deactivating agent for the neutralization of Trilaciclib injection 10 mg/mL and Trilaciclib API with respect to concentration and time. This method developed based by RP-HPLC.
Title: Identification of deactivation procedure for Trilaciclib
Description:
The Indian health-care facilities (HCFs) made some guidelines related to cytotoxic drugs so called cytotoxic policy for patient safety and health-care worker safety, and environmental monitoring program as per the available international guidelines.
Trilaciclib is indicated for the treatment of patients with multiple myeloma and chemically it is a tetra peptide epoxy ketone and an analog of epoxomicin.
Analytical method for the detection of Deactivating agent and concentration play an impartment role in the pharmaceuticals especially with cytotoxic molecules after completion of manufacturing and testing is mandatory to follow the safety protocol to dispose those materials.
The present invention provides to identify the suitable deactivating agent for the neutralization of Trilaciclib injection 10 mg/mL and Trilaciclib API with respect to concentration and time.
This method developed based by RP-HPLC.
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