Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Studies on Tetanus Antitoxins
View through CrossRef
Abstract
In this paper the antigenic structure of tetanus toxin is described. It was shown that the toxin as well as the toxoid is carrying at least four antigenic determinants. In addition to antigen-[2] already described in a previous paper, two new degraded antigens could be isolated: antigen-[1] by preparative polyacrylamide gel electrophoresis of spontaneously degraded toxin, and antigen-[3] by pH treatment of toxin. All degraded antigens are immunogenic and nontoxic. The presence of a fourth antigenic determinant on tetanus toxin could be demonstrated only after successive absorption of rabbit antitoxic serum with the antigens-[1], -[2] and -[3]. Toxin-neutralizing antibodies remained in the absorbed serum which reacted only with tetanus toxin and tetanus toxoid. Antibodies against the four antigenic determinants are present in antitoxic serum from rabbits and horses. Human antiserum, however, contained antibodies to these determinants, anti-1 antibodies being absent. All four antitoxins could neutralize tetanus toxin in vivo.
Title: Studies on Tetanus Antitoxins
Description:
Abstract
In this paper the antigenic structure of tetanus toxin is described.
It was shown that the toxin as well as the toxoid is carrying at least four antigenic determinants.
In addition to antigen-[2] already described in a previous paper, two new degraded antigens could be isolated: antigen-[1] by preparative polyacrylamide gel electrophoresis of spontaneously degraded toxin, and antigen-[3] by pH treatment of toxin.
All degraded antigens are immunogenic and nontoxic.
The presence of a fourth antigenic determinant on tetanus toxin could be demonstrated only after successive absorption of rabbit antitoxic serum with the antigens-[1], -[2] and -[3].
Toxin-neutralizing antibodies remained in the absorbed serum which reacted only with tetanus toxin and tetanus toxoid.
Antibodies against the four antigenic determinants are present in antitoxic serum from rabbits and horses.
Human antiserum, however, contained antibodies to these determinants, anti-1 antibodies being absent.
All four antitoxins could neutralize tetanus toxin in vivo.
Related Results
Profil Kasus Tetanus Anak di RS Prof. Dr. R.D. Kandou Manado
Profil Kasus Tetanus Anak di RS Prof. Dr. R.D. Kandou Manado
Latar belakang.Insiden dan angka kematian tetanus anak masih cukup tinggi di Indonesia. Di Bagian Ilmu Kesehatan Anak RSCM Jakarta, dari tahun 1990 sampai 1993 dirawat rata-rata 20...
Proportion of Births Protected Against Neonatal Tetanus and Its Associated Factors Among Mothers Who Gave Birth Within the Past 6 Months in Gozamn District, Northwest Ethiopia, 2022
Proportion of Births Protected Against Neonatal Tetanus and Its Associated Factors Among Mothers Who Gave Birth Within the Past 6 Months in Gozamn District, Northwest Ethiopia, 2022
Abstract
Introduction:
An estimated 3.3 million newborn deaths occur each year around the world, with 9,000 babies dying every day in their first 28 days. Neonatal tetanus...
Awareness of Women about Tetanus in Baghdad
Awareness of Women about Tetanus in Baghdad
Background: Tetanus toxoid (TT) vaccine is still recommended for pregnant women even in countries that declared elimination of neonatal tetanus (NT) and consequently the maternal t...
Tetanus: A Potential Public Health Threat in Times of Disaster
Tetanus: A Potential Public Health Threat in Times of Disaster
AbstractBackground:Tetanus is a potentially fatal condition that is rare in urban environments but is seen in developing countries and post-natural-disaster. Therefore, the purpose...
Magnitude of Tetanus Toxoid Immunization and Associated Factors among Pregnant Women in Ethiopia
Magnitude of Tetanus Toxoid Immunization and Associated Factors among Pregnant Women in Ethiopia
Background:Maternal and neonatal tetanus remains a major global health problem. Two-thirds of the cases of neonatal tetanus occur in the poorest and least developed countries, incl...
Indian experience of tetanus - A study from south India
Indian experience of tetanus - A study from south India
"Abstract: Introduction: Tetanus is an old world disease where 2 centuries ago people had realized the link between wound leading to muscle spasm and fatality, Even today there are...
ADMINISTRATION OF TETANUS TOXOID IMMUNIZATION TO PREGNANT MOTHERS DURING THE COVID-19 PANDEMIC
ADMINISTRATION OF TETANUS TOXOID IMMUNIZATION TO PREGNANT MOTHERS DURING THE COVID-19 PANDEMIC
Background: The outbreak of the Covid-19 pandemic in Indonesia impacts women's reproductive health services, including pregnant women services that meet the standard, namely the ad...
Factors Associated with Uptake of Tetanus Toxoid Vaccine among Pregnant Women Attending Antenatal Clinic at Nyamagana Health Centre Mwanza-Tanzania
Factors Associated with Uptake of Tetanus Toxoid Vaccine among Pregnant Women Attending Antenatal Clinic at Nyamagana Health Centre Mwanza-Tanzania
Background: Maternal and neonatal tetanus remains a public health problem in low- and middle-income countries despite increasing investment in tetanus toxoid vaccines TTV). Tanzani...