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Chromosomal abnormalities in recurrent spontaneous abortions: A retrospective study
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Purpose: Evaluation of recurrent spontaneous abortions (RSA) can be
challenging for a Obstetrician. In case of early first trimester
abortions, chromosomal abnormalities can be identified as an important
cause. We analysed the RSA cases followed up and diagnosed in the
Genetic Clinic or Genetic Lab of 2 hospitals in the region. Methods:
Those couples with 3 or more spontaneous abortions were included in the
analysis. Karyotyping was one using standard protocol with G-banding and
reporting as per ISCN guidelines. Results: Of 97 RSA couples, 20 showed
chromosomal abnormalities, and 15 of these had balanced chromosomal
rearrangements. The age ranged from 22 years to 37 years, and the median
number of abortions was 4. Complex chromosomal rearrangement was seen in
2 couples, in one partner. The spectrum of chromosomal anomalies in
couples with RSA is discussed here. Conclusions: Frequency of
chromosomal abnormalities in RSA was higher in present study compared to
previous studies. Reciprocal translocations were commonest abnormality.
Title: Chromosomal abnormalities in recurrent spontaneous abortions: A retrospective study
Description:
Purpose: Evaluation of recurrent spontaneous abortions (RSA) can be
challenging for a Obstetrician.
In case of early first trimester
abortions, chromosomal abnormalities can be identified as an important
cause.
We analysed the RSA cases followed up and diagnosed in the
Genetic Clinic or Genetic Lab of 2 hospitals in the region.
Methods:
Those couples with 3 or more spontaneous abortions were included in the
analysis.
Karyotyping was one using standard protocol with G-banding and
reporting as per ISCN guidelines.
Results: Of 97 RSA couples, 20 showed
chromosomal abnormalities, and 15 of these had balanced chromosomal
rearrangements.
The age ranged from 22 years to 37 years, and the median
number of abortions was 4.
Complex chromosomal rearrangement was seen in
2 couples, in one partner.
The spectrum of chromosomal anomalies in
couples with RSA is discussed here.
Conclusions: Frequency of
chromosomal abnormalities in RSA was higher in present study compared to
previous studies.
Reciprocal translocations were commonest abnormality.
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