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Clinical significance of serum helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina
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Abstract
Objective: We investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA).
Methods: Serum CagA levels were measured using ELISA. Demographic data, serum biomarkers, and SYNTAX scores were collected. Patients were followed up for one year for major adverse cardiac events (MACE).
Results: CagA-positive UA patients had higher total cholesterol and hsCRP levels, and SYNTAX scores. CagA levels correlated positively with TC, hsCRP, and SYNTAX scores. Kaplan-Meier analysis showed shorter MACE-free survival in CagA-positive UA patients. CagA levels predicted MACE occurrence within one year, along with SYNTAX scores. Conclusion: Serum H. pylori CagA antibody positivity is associated with worse prognosis in UA patients. CagA levels correlate with lipid metabolism and inflammatory markers.
Springer Science and Business Media LLC
Title: Clinical significance of serum helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina
Description:
Abstract
Objective: We investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA).
Methods: Serum CagA levels were measured using ELISA.
Demographic data, serum biomarkers, and SYNTAX scores were collected.
Patients were followed up for one year for major adverse cardiac events (MACE).
Results: CagA-positive UA patients had higher total cholesterol and hsCRP levels, and SYNTAX scores.
CagA levels correlated positively with TC, hsCRP, and SYNTAX scores.
Kaplan-Meier analysis showed shorter MACE-free survival in CagA-positive UA patients.
CagA levels predicted MACE occurrence within one year, along with SYNTAX scores.
Conclusion: Serum H.
pylori CagA antibody positivity is associated with worse prognosis in UA patients.
CagA levels correlate with lipid metabolism and inflammatory markers.
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