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Supplementary Figures from Neddylation Blockade Diminishes Hepatic Metastasis by Dampening Cancer Stem-Like Cells and Angiogenesis in Uveal Melanoma
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<p>Figure S1-The specificity of NAE1 antibody for immunohistochemical analysis was verified; Figure S2-MLN4924 induces apoptosis in human UM cells; Figure S3-MLN4924 is synergistic with vinblastine to induce apoptosis in UM cells; Figure S4-MLN4924 induces DNA damage response and G2/M-phase arrest in UM cells; Figure S5-Inhibiting checkpoint of DNA damage potentiates the cytotoxicity of MLN4924; Figure S6-MLN4924 suppresses ALDH+ cells in UM cells; Figure S7-Slug is required for maintenance of CSCs properties in UM cells; Figure S8-MLN4924 inhibits migration and invasion of human UM cells; Figure S9-MLN4924 inhibits hepatic metastasis of UM cells by attenuating VEGF-C secretion.</p>
American Association for Cancer Research (AACR)
Title: Supplementary Figures from Neddylation Blockade Diminishes Hepatic Metastasis by Dampening Cancer Stem-Like Cells and Angiogenesis in Uveal Melanoma
Description:
<p>Figure S1-The specificity of NAE1 antibody for immunohistochemical analysis was verified; Figure S2-MLN4924 induces apoptosis in human UM cells; Figure S3-MLN4924 is synergistic with vinblastine to induce apoptosis in UM cells; Figure S4-MLN4924 induces DNA damage response and G2/M-phase arrest in UM cells; Figure S5-Inhibiting checkpoint of DNA damage potentiates the cytotoxicity of MLN4924; Figure S6-MLN4924 suppresses ALDH+ cells in UM cells; Figure S7-Slug is required for maintenance of CSCs properties in UM cells; Figure S8-MLN4924 inhibits migration and invasion of human UM cells; Figure S9-MLN4924 inhibits hepatic metastasis of UM cells by attenuating VEGF-C secretion.
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