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Association between erythrocyte 2,3-diphosphoglycerate levels and reproductive capacity in Long—Evans rats
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Summary.
During genetic selection of rats for high and low levels of red cell 2,3-diphosphoglycerate (DPG) the decreased fertility in Low-DPG animals was due to significantly (P < 0·01) fewer offspring born per litter. The rat lines were intercrossed and animals at the tails of the F2 2,3-diphosphoglycerate distribution were mated. Subsequent matings of F3 offspring were monitored. Low-DPG F3 pregnant females killed at 20 days of gestation showed significantly (P < 0·05) fewer corpora lutea than High-DPG F3 females. There were also significantly (P < 0·01) fewer corpora lutea in Low-DPG line rats compared to High-DPG rats. It is concluded that the relationship between 2,3-diphosphoglycerate levels and fertility is not due to inbreeding but to a possible genetic linkage, a shared biochemical determinant or a relationship through the effect of 2,3-diphosphoglycerate levels on oxygen delivery to tissues.
Title: Association between erythrocyte 2,3-diphosphoglycerate levels and reproductive capacity in Long—Evans rats
Description:
Summary.
During genetic selection of rats for high and low levels of red cell 2,3-diphosphoglycerate (DPG) the decreased fertility in Low-DPG animals was due to significantly (P < 0·01) fewer offspring born per litter.
The rat lines were intercrossed and animals at the tails of the F2 2,3-diphosphoglycerate distribution were mated.
Subsequent matings of F3 offspring were monitored.
Low-DPG F3 pregnant females killed at 20 days of gestation showed significantly (P < 0·05) fewer corpora lutea than High-DPG F3 females.
There were also significantly (P < 0·01) fewer corpora lutea in Low-DPG line rats compared to High-DPG rats.
It is concluded that the relationship between 2,3-diphosphoglycerate levels and fertility is not due to inbreeding but to a possible genetic linkage, a shared biochemical determinant or a relationship through the effect of 2,3-diphosphoglycerate levels on oxygen delivery to tissues.
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