469-P: Both LDL Cholesterol and LDL Particles Associated with MACE in Tibetan Patients with Type 2 Diabetes

Background: LDL-C remains the primary treatment target for reducing major cardiovascular events (MACE) in patients with T2D. Our previous study revealed T2D patients residing in the Tibet Plateau exhibited elevated levels of LDL-C, LDL-particle number (LDL-P), but not small density LDL particles compared to those living in lowland areas. Whether the LDL-P is an independent predictor of MACE in Tibetan patients with T2D is unclear and is addressed in this study. Methods: We conducted a perspective cohort study involving 165 patients, including 17 patients with established cardiovascular disease (13 of whom had angiographically confirmed stable coronary heart disease and 4 of whom had experienced stroke). Their demographic information, clinical feature, and standard lipid concentrations were collected and evaluated. LDL-P was measured by Nuclear magnetic resonance (NMR) spectroscopy. The primary outcome was MACE, including death from cardiovascular cause, non-fatal stroke, and non-fatal myocardial infarction. Cox proportional hazard models were utilized to examine the association between LDL-C and LDL-P with MACE. Results: Over a median follow-up period of 26 months, 18 patients suffered MACE. The multivariate adjusted Cox regression model revealed a significant association between both LDL-C and LDL-P with MACE (Table 1). Conclusion: Both LDL-C and LDL-P associated with MACE in Tibetan patients with T2D. Disclosure C. Zhang: None. W. Suyuan: None. M. Li: None. Funding Sichuan Medical Association (S21056)