Genomic analysis of sites that present somatic mutations in mice

The recognition that genomes not only contain all the genetic material of a particular organism, but also have their historical information, has increased the range of phylogenetic studies, which provide evolutionary information. The development of complete genome sequencing techniques, in conjunction with the development of bioinformatics has led to a vertiginous growth in the amount of information deposited in the data banks, and in novel tools for analysis. Genomic analyzes allow us to obtain a comprehensive study of the functioning, content, evolution and origin of genomes.  It has been determined that there are dramatic rearrangements in the genomes, thus demonstrating genomic plasticity. It has been concluded that genomic rearrangements can occur as a consequence of events in which sites of small or large regions within the genome can be deleted, moved, exchanged, or inserted. Within these mentioned events are the deletions or deletions that consist in the loss of a DNA fragment of a chromosome, the size includes a range so diverse ranging from a nucleotide to large cytogenetically visible regions. There is a large number of studies that indicate that in various animal groups there are species in which genomic rearrangements occur during development whose functional relevance is still unknown. This project aims to focus on the study of recurrent deletion sites using the mouse as a study model with the main objective of identifying, characterizing and evaluating the presence of these genomic rearrangements in different genomes of mammals using the mouse genome as a study model for determine its possible functional and evolutionary relevance. The results obtained from this proposal will allow us to generate a general overview of the role played by these sequences, their possible correlation with the genome of other mammalian species will allow us to generate phylogenetic reconstructions.