Co-existence of Fahr’s syndrome with a Meningioma: A Case Report and Literature review.

Abstract Bilateral basal ganglia calcification is associated with various neurological, metabolic and infectious conditions. Fahr’s syndrome, characterized by basal ganglia calcification in the presence of secondary causes, is uncommon. The association of bilateral basal ganglia calcification with a brain tumour has only been rarely described. We present a case of Fahr’s syndrome coexisting with a calcified meningioma. A 62-year-old woman with a history of total thyroidectomy presented with a generalized tonic-clonic seizure. Imaging revealed bilateral basal ganglia calcifications and a calcified meningioma. Biochemical analysis confirmed hypocalcemia with an inappropriately low parathyroid hormone level suggestive of primary hypoparathyroidism, associated with hyperphosphatemia and hypomagnesemia. Despite magnesium correction, persistent hypocalcemia was noted, attributed to possible parathyroid gland injury during thyroidectomy. The co-occurrence of a cerebral tumour with Fahr’s syndrome has not been previously reported. This case highlights the importance of correlation of biochemical evaluation with neuroimaging.