Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing

Pharmacokinetic modeling helps to estimate the ADME parameters of all the natural and synthetic drug substances in humans and animals. There are two types of approaches for predicting the kinetic processes inside the body i.e., model approach and model independent approach. Model approach is further divided into compartmental and physiological models and model independent approach consists of non-compartmental models. Compartmental modeling is the most widely used approach. It visually shows the rate processes of drug deposition and also predict the drug concentration time graph. Compartmental model consists of catenary and mammillary models. Mammillary models can either be one compartment, multi compartment or two compartments. The physiologically based pharmacokinetic models consists of compartments that correlates with various body tissues, connected by blood circulatory system. Another name for non- compartmental analysis is model-independent approach that means it does not require any compartment model.