To Investigate the Clinical Effect of Sodium Hyaluronate Injection Combined With Zhengqing Fengtongning Injection in the Treatment of Knee Osteoarthritis

Objective: To investigate the effect of sodium hyaluronate injection combined with Zhengqing Fengtongning injection in the treatment of knee osteoarthritis. Methods: A total of 68 patients with knee osteoarthritis admitted to the Department of Acupuncture and Moxibustion of Yueyang Baoxin Orthopedic Hospital from June 2024 to June 2025 were collected as the research objects. According to the digital random method, they were divided into the control group and the observation group, with 34 cases in each group. The control group was treated with sodium hyaluronate injection, and the observation group was treated with sodium hyaluronate injection combined with Zhengqing Fengtongning injection. The curative effect, knee joint function, pain and stiffness were compared between the two groups before treatment and 1, 2 and 3 weeks after treatment. Results: Compared before treatment, the WOMAC score and VAS score of the two groups were significantly reduced at each time point after treatment (P<0.05), and the decrease of WOMAC score in the observation group was significantly greater than that in the control group (P<0.05). The improvement of each dimension and total score of SF-36 quality of life in the observation group was significantly better than that in the control group 3 weeks after treatment (P<0.05). The total effective rate of the observation group was 91.18%, which was significantly higher than 73.53% of the control group (P<0.05). During the treatment, there were no serious adverse reactions in the two groups, and only a few patients had slight injection site discomfort, which was relieved by themselves. Conclusion: Sodium hyaluronate injection combined with Zhengqing Fengtongning injection in the treatment of knee osteoarthritis can effectively relieve knee joint pain, improve joint function and quality of life, and has good safety, which is worthy of further clinical application.