Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Rab GTPase localization and Rab cascades in Golgi transport
View through CrossRef
Rab GTPases are master regulators of membrane traffic. By binding to distinct sets of effector proteins, Rabs catalyse the formation of function-specifying membrane microdomains. They are delivered to membranes by a protein named GDI (guanine-nucleotide-dissociation inhibitor) and are stabilized there after nucleotide exchange by effector binding. In the present mini-review, I discuss what we know about how Rab GTPases are delivered to the correct membrane-bound compartments and how Rab GTPase cascades order Rabs within the secretory and endocytic pathways. Finally, I describe how Rab cascades may establish the distinct compartments of the Golgi complex to permit ordered processing, sorting and secretion of secretory cargoes.
Title: Rab GTPase localization and Rab cascades in Golgi transport
Description:
Rab GTPases are master regulators of membrane traffic.
By binding to distinct sets of effector proteins, Rabs catalyse the formation of function-specifying membrane microdomains.
They are delivered to membranes by a protein named GDI (guanine-nucleotide-dissociation inhibitor) and are stabilized there after nucleotide exchange by effector binding.
In the present mini-review, I discuss what we know about how Rab GTPases are delivered to the correct membrane-bound compartments and how Rab GTPase cascades order Rabs within the secretory and endocytic pathways.
Finally, I describe how Rab cascades may establish the distinct compartments of the Golgi complex to permit ordered processing, sorting and secretion of secretory cargoes.
Related Results
STX5’s flexibility in SNARE pairing supports Golgi functions
STX5’s flexibility in SNARE pairing supports Golgi functions
AbstractThe intracellular transport system is an evolutionally conserved, essential, and highly regulated network of organelles and transport vesicles that traffic protein and lipi...
Abstract 1330: Golgi disorganization and ER stress: the mechanism underlying alcohol-mediated prostate cancer progression
Abstract 1330: Golgi disorganization and ER stress: the mechanism underlying alcohol-mediated prostate cancer progression
Abstract
The link between prostate cancer (PCa) risk and alcohol consumption has long been debated. In our recent analysis of the epidemiologic evidence for this lin...
Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking
Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking
Abstract
Most proteins in the secretory pathway are glycosylated. However, the role of glycans in the membrane trafficking is still unclear. Here...
Lyn Hitches a Ride on the Golgi
Lyn Hitches a Ride on the Golgi
Lyn is a member of the Src family of nonreceptor tyrosine kinases, which are cytosolic proteins that associate with the cytosolic side of the plasma membrane. Kasahara
...
Indoor Localization System Based on RSSI-APIT Algorithm
Indoor Localization System Based on RSSI-APIT Algorithm
An indoor localization system based on the RSSI-APIT algorithm is designed in this study. Integrated RSSI (received signal strength indication) and non-ranging APIT (approximate pe...
Les cascades électromagnétiques cosmologiques comme sondes du milieu intergalactique
Les cascades électromagnétiques cosmologiques comme sondes du milieu intergalactique
Cette thèse vise à étudier le phénomène dit de " cascades électromagnétiques cosmologiques ". Ces cascades sont typiquement générées dans le milieu intergalactique par l'absorption...
The K/HDEL receptor does not recycle, but instead acts as a Golgi-gatekeeper
The K/HDEL receptor does not recycle, but instead acts as a Golgi-gatekeeper
Abstract
The K/HDEL receptor (ER retention defective 2 or ERD2) does not recycle between compartments when sorting ER chaperones, contrary to the favoured model. A conserve...