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Structural chemoproteomics and drug discovery
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AbstractOur laboratories have developed several technologies to accelerate drug discovery process on the basis of structural chemoproteomics. They include SPS™ technology for the efficient determination of protein structures, SCP™ technology for the rapid lead generation and SDF™ technology for the productive lead optimization. Using these technologies, we could determine many 3D structures of target proteins bound with biologically active chemicals including the structure of phosphodiesterase 5/Viagra complex and obtain highly potent compounds in animal models of obesity, diabetes, cancer and inflammation. In this paper, we will discuss concepts and applications of structural chemoproteomics for drug discovery. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2005
Title: Structural chemoproteomics and drug discovery
Description:
AbstractOur laboratories have developed several technologies to accelerate drug discovery process on the basis of structural chemoproteomics.
They include SPS™ technology for the efficient determination of protein structures, SCP™ technology for the rapid lead generation and SDF™ technology for the productive lead optimization.
Using these technologies, we could determine many 3D structures of target proteins bound with biologically active chemicals including the structure of phosphodiesterase 5/Viagra complex and obtain highly potent compounds in animal models of obesity, diabetes, cancer and inflammation.
In this paper, we will discuss concepts and applications of structural chemoproteomics for drug discovery.
© 2005 Wiley Periodicals, Inc.
Biopolymers (Pept Sci), 2005.
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