Correlation between body mass index and perianal abscess hazards: a Mendelian randomization investigation

Abstract Background:Perianal abscess is an infectious disease that frequently affects the perianal region. Body mass index (BMI) is a commonly used statistic to assess weight and weight gain. Although there is evidence linking obesity to several medical conditions, the relationship between BMI and perianal abscesses remains unclear. Whether BMI influences the likelihood of perianal abscess remains unclear. Methods A two-sample Mendelian randomization (MR) study was conducted using weighted average, weighting the median, weighted inverse-variance weighted (IVW), and MR-Egger regression approaches. Using the accessible to everybody summarized collections of GWAS meta-analyses for BMI among people of South Asian descent (n = 8,658) as being exposed, a genome-wide association experiment (GWAS) for anal and rectal abscess from people who are involved in the OpenGWAS database (total n = 183 710; case = 1 287, control = 182 423) was used as the outcome. Results: We used GWASs to find 29 single nucleotide polymorphisms (SNPs) of genome-wide relevance, using BMI as the variable in question. The IVW technique indicateds that there was not enough information to determine a cause-and-effect link between BMI and perianal abscess (Beta = -0.093, SE = 0.097, P = 0.340). An analysis of MR-Egger regression revealed a lack of causality between BMI and perianal abscess (beta = -0.254, SE = 0.177, P = 0.162). The analysis also showed that directed multiplication did not influence the results (intercept = 0.024; P = 0.285). Furthermore, there is no evidence that a link between BMI and perianal abscess exists according to the weighted mean (Beta = -0.207, SE = 0.182, P = 0.813) or weighted median (Beta = -0.126, SE = 0.139, P = 0.363). The funnel plot and Cochran's Q test, which also revealed no evidence of diversity or imbalances, demonstrated that there was no directional pleiotropy. In summary, there were insufficient data from the MR analysis to substantiate the theory linking a greater BMI with a higher incidence of perianal abscess.