Development and Evaluation of Herbal Formulation for Obesity

Obesity is one of the most prevalent health concerns among all age groups and populations worldwide, resulting in a significant increase in mortality and morbidity related to metabolic disorders. The present study involves formulation development and evaluation of effervescent granules prepared by using herbal extract mixture (hydro-alcoholic extract of fruits of Garcinia indica, seeds of Achyranthes aspera & raw beans of Coffee arabica L.) along with its in-vitro anti-obesity activity. Hydro-alcoholic extract of three plant materials were prepared by soxhlet extraction method. Effervescent granules were prepared & their evaluation was done for physical properties like angle of repose, bulk density, tap density, car’s index, hausner’s ratio & effervescent cessation time. All the batches showed acceptable physical properties. Furthermore, In-vitro lipase inhibitory and α-amylase inhibitory activities were studied for herbal extract mixture at different concentration (50, 100, 150, 200, 250, 300) μg/ml. Herbal extract mixture at concentration of 300 μg/ml showed highest lipase and ᾳ amylase inhibitory action, i.e., 83.32± 10.47 and 69.14± 7.22 respectively. This study is possibly advantageous as the bottom line for further formulation for herbal extract based effervescent products.