2031-LB: Correlation between Fructosamine and Continuous Glucose Monitoring in the Preoperative Setting

Introduction and Objective: Fructosamine reflects glycemic control over 2-3 weeks via albumin turnover, offering a short-term alternative to HbA1c. Its perioperative use has increased, but no consensus exists on the best formula for estimating average glucose from fructosamine. This study assessed the correlation between CGM and fructosamine and identified the best-aligned formula preoperatively. Methods: This retrospective analysis included 30 adult surgical patients with paired preoperative CGM and fructosamine data. Pearson correlations evaluated relationships between fructosamine, CGM-derived mean blood glucose (BG), and estimated A1c using three available formulas. Results: Fructosamine correlated significantly with CGM-derived mean BG (r(28) = 0.39, p = 0.04). Pearson correlations comparing CGM-derived mean BG with estimates from three fructosamine-to-HbA1c conversion formulas showed moderate, significant correlations across all models (r(28) = 0.39, p = 0.03). The Alarcon formula exhibited the strongest correlation, though all three showed similarly significant results. Conclusion: The significant correlation between fructosamine and CGM-derived mean BG supports its role as a short-term glycemic marker in the preoperative setting. The Alarcon formula appears most suitable for estimating glucose and HbA1c from fructosamine, aiding in pre-surgical glycemic assessment. Disclosure H. Lee: None. A. Behrens: None. V. Nelson: None. T. Adel: None. A. Thorgerson: None. A.Z. Dawson: None. C.E. Mendez: Consultant; Siemens Healthcare Diagnostics.