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Preparation and Evaluation of Acebutolol Mucoadhesive Films
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Mucoadhesive drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form. A mucoadhesive film for systemic administration of acebutolol has been developed using HPMC K4M, HPMC E5, HPMC E15, Carbopol and Eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, disintegration, drug release, weight variation, folding endurance, etc. The in vitro disintegration time and dissolution time of the optimized formulation (F12) was found to be 9 seconds and 99.23% within 8 mins respectively. FTIR studies showed no drug polymer interaction takes place. These results revealed that mucoadhesive films of acebutolol could be formulated for immediate drug release to ensure symptomatic relief which leads to improved patient compliance in the management of hypertension.
Keywords
Acebutolol; Solvent casting; HPMC E15; FTIRs; Mucoadhesive; Carbopol
ASEAN Federation for Psychiatry and Mental Health
Title: Preparation and Evaluation of Acebutolol Mucoadhesive Films
Description:
Mucoadhesive drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form.
A mucoadhesive film for systemic administration of acebutolol has been developed using HPMC K4M, HPMC E5, HPMC E15, Carbopol and Eudragit and ethanol by solvent casting method.
The prepared films characterized by means of film thickness, swelling capacity, disintegration, drug release, weight variation, folding endurance, etc.
The in vitro disintegration time and dissolution time of the optimized formulation (F12) was found to be 9 seconds and 99.
23% within 8 mins respectively.
FTIR studies showed no drug polymer interaction takes place.
These results revealed that mucoadhesive films of acebutolol could be formulated for immediate drug release to ensure symptomatic relief which leads to improved patient compliance in the management of hypertension.
Keywords
Acebutolol; Solvent casting; HPMC E15; FTIRs; Mucoadhesive; Carbopol.
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