Abstract 725: Prostate cancer risk disparities and sociocultural factors in men of African ancestry

Abstract Introduction: The purpose of this research study was to quantify the prostate cancer (PCa) mortality rate in Men of African Ancestry (MAA) living in the State of Florida, the tri-county region of South Florida including Broward, Palm Beach, and Miami-Dade, and to explore the embodiment of sociocultural factors that contribute to the PCa disparity in the United State (U.S.). Method: A quantitative, non-experimental, descriptive study design was used to identify differences in the resident PCa mortality rate in MAA stratified based on single race of Black and birth origin of Haiti (HA), Jamaica (JA), or the United States (U.S.). The intersection of health disparities and the embodiment of chronic exposure to sociocultural stressors was also explored. Results: The Paired t-Test was used for statistical testing. The results indicated death from PCa is a health disparity in MAA in Florida when examined in aggregate by ancestry and disaggregate by birth origin. In the state of Florida, when the PCa death rate was viewed in aggregate by ancestry, a significant difference was found between MAA and Men of European Ancestry (MEA) (t(2)=4.303, p≤.01). There was a statistically significant relationship found between being MAA and death from PCa (r=.866, p≤.01). This suggests there are place based health disparities among MAA in the State of Florida. When the PCa mortality rate in MAA in the tri county region of South Florida was examined in aggregate by ancestry versus disaggregate by birth origin a significant difference was shown between MAA and HA born men (t(2)=4.30, p=0.05). No difference was shown between MAA and U.S., or JA born men. By county, the highest death rate was found in JA born men in Miami-Dade, and HA born men in Broward and Palm Beach. Overall, the lowest death rates in each county were found in U.S. born men. The results suggest that there are clear placed based and birth origin disparities in the South Florida region. Conclusions: Examining differences in the PCa mortality rates in MAA in disaggregate by birth origin provides opportunity for the observation of sociocultural factors that affect health such as cultural beliefs and fears, chronic exposure to stressors such as structural and explicit racism and racialization in the U.S, immigration status and barriers to healthcare; all sociocultural factors that if examined may aid in explaining the increased rate of PCa death experienced by MAA and why the disparity exists. Citation Format: Joan M. Brown. Prostate cancer risk disparities and sociocultural factors in men of African ancestry [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 725.