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CDC20 is a Potential Prognostic and Immunological Biomarker in Pan-Cancer
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Abstract
BackgroundCDC20(cell division cycle 20 homologue) plays a vital role in the cell cycle progression through targeting key substrates for destruction. Current studies have shown that CDC20 functions as an oncogene in various cancers. However, the potential correlations of CDC20 with prognosis and immune infiltrates in different cancers remain unclear.ResultCDC20 expression was higher in most cancers, compared with normal tissues, and the high expression of CDC20 was correlated with poor prognosis and a higher pathological stage. Furthermore, there were significant correlations between CDC20 dysregulation with tumor mutation burden(TMB), microsatellite instability(MSI), tumor microenvironment and tumor- and immune-related genes.ConclusionCDC20 may be used as a potential prognostic and immunotherapeuticbiomarker which affects tumor progression.
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Title: CDC20 is a Potential Prognostic and Immunological Biomarker in Pan-Cancer
Description:
Abstract
BackgroundCDC20(cell division cycle 20 homologue) plays a vital role in the cell cycle progression through targeting key substrates for destruction.
Current studies have shown that CDC20 functions as an oncogene in various cancers.
However, the potential correlations of CDC20 with prognosis and immune infiltrates in different cancers remain unclear.
ResultCDC20 expression was higher in most cancers, compared with normal tissues, and the high expression of CDC20 was correlated with poor prognosis and a higher pathological stage.
Furthermore, there were significant correlations between CDC20 dysregulation with tumor mutation burden(TMB), microsatellite instability(MSI), tumor microenvironment and tumor- and immune-related genes.
ConclusionCDC20 may be used as a potential prognostic and immunotherapeuticbiomarker which affects tumor progression.
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