“TO COMPARE THE EFFICACY OF INTRAVENOUS PARACETAMOL VS COMBINATION OF INTRAVENOUS PARACETAMOL AND MAGNESIUM SULPHATE ON POST OPERATIVE PAIN RELIEF.”

Introduction: Recent studies have shown the positive effect of magnesium sulphate as an adjunct on post-operative pain relief. This study is comparing effect of paracetamol with and without magnesium sulphate as an adjunct on post operating pain relief. AIMS: “To compare the efcacy of intravenous paracetamol vs combination of intravenous paracetamol and magnesium sulphate on post operative pain relief.” (1) To compare the duration of post operative Objectives: analgesia based on VAS score. (2) To note the requirement of rescue analgesia in the rst 24 hrs post operative period. This ra Materials And Methods: ndomised trial was conducted on 30 patients at Dr. D.Y.Patil medical college and research hospital. The patients who were candidates were randomised into two groups, Group 1 (n=15) and Group 2 (n=15). Spinal anaesthesia was given to all the patients. Group 1 were given 1 gm of IV paracetamol (100ml) with 100 ml of normal saline and group 2 were given 1gm of IV paracetamol (100ml) with 50mg/kg Magnesium sulphate in 100 ml of normal saline (max 2gm). VAS (visual analogue score) was used to assess post operative pain relief and requirement of rescue analgesia post operatively was measured. Result: There was a decrease inn rescue analgesic consumption and pain in the group receiving MgSo4 as an adjunct. In comparison to group 1, Group 2 showed statistically signicant reduction in post operative pain at 12, 24 and 36 hours. Intravenous MgSo4 with Conclusion: paracetamol is effective in reducing post operative pain and requirent of total opioid consumption in 72 hour post operative period as well as increased total duration of analgesia.