International Society of Urologic Pathology (ISUP) Grade Grouping in Prostatic Adenocarcinoma and Its Prognostic Implications

Abstract Objectives: International Society of Urologic Pathology (ISUP) grade grouping of prostatic adenocarcinoma was introduced to simplify gleason score-related categories of prostatic adenocarcinoma. Prognostic reproducibility of ISUP/WHO grade grouping was not well studied in our population, therefore in this study, our aim was to evaluate the association of ISUP/WHO grade groups with various pathological prognostic parameters.Results: This retrospective cross-sectional study was done in Liaquat National Hospital, Department of Histopathology from February 2011 to January 2018, over a period of seven years. A total of 172 patients were included in this study. The mean age of patients was 66.97±10.51 years. In this study we noted, 27 (15.7%) cases of grade group 1, 22 (12.8%) of grade group 2, 30 (17.4%) of grade group 3, 40 (23.3%) of grade group 4 and 53 (30.8%) of grade group 5. A significant association of tumor grade with perineural invasion (p=0.005) and tumor volume (tumor quantification was noted. In this study, we found a high frequency of grade group 4 and 5 in prostatic adenocarcinoma. Moreover, a significant association of grade groups was noted with perineural invasion and tumor volume, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.