Network Analysis for Estimating Standardization Trends in Genomics

Abstract With the development of biotechnology in genomics, such as droplet digital PCR, sequencing device, gene analysis software, an increase in the clinical application of those new developed technologies in genomics is observed. However, the lack of established international standards regarding the use of genomics in clinics is of concern. To visualize trend of international standards in clinical genomics and explore high demanded sub-specific field, we performed a social network analysis. We searched 16,538 articles using the search keywords, “genomics and standard” and “clinical genomic sequence and standard”. All terms extracted from full text articles were classified into academic and technical categories and conducted general linear model analysis. Assuming from the results, research in the fields of software, proteomics and genetics terminology categories is likely to increase. From our results, such international critical issue of genomics, human genome project in 2003, primary US-FDA approval of sequencing device in 2013, and pandemic state of COVID-19 in 2020, were affected to research of standard in genomics. In further proposal and standardization of new items, summing critical social issues and research trends, we could suggest and considering promising sub-specific field of genomics.