ANTIBACTERIAL EFFECT OF EUGENIA POLYANTHA WIGHT WITH CORYNEBACTERIUM DIPHTHERIAE NON-TOXIGENIC

Introduction: Corynebacterium diphtheriae is a bacteria that causes diphtheria. In recent years, the bacterium is resistant to antibiotics. Eugenia polyantha wight might be a suitable antibiotic alternative as it has antibacterial effect against Staphylococcus aureus. The content of the antibacterial compound in Eugenia polyantha wight at specific concentrations is expected to be able to kill the Corynebacterium diphtheriae. Purpose: This study aimed to examine the antibacterial effect of Eugenia polyantha wight to Corynebacterium diphtheriae non-toxic. Method: Bay leaf extract (Eugenia polyantha wight) made with maceration method. This research is an experimental study conducted in vitro using a microdilution test on 96 well plates then count value with the streaking method to find out MBC. Results: bactericidal power was quite effective at the concentration of 40%, while at the concentration of 80%-100% has very strong bactericidal power that could destroy the growth of bacteria 99.9%. The higher the concentration of bay leaves extract, the higher the bactericidal power of bacteria Conclusion: Eugenia polyantha wight has an antibacterial effect against Corynebacterium diphtheriae non-toxic.