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Effects of Minerals on Neomycin Production by Streptomyces fradiae
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A study was made on the mineral requirements of
Streptomyces fradiae
strain 3535 for neomycin production. It was observed that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production were 10.8, 1.0, and 0.115 μg, respectively. K
2
HPO
4
was required at a concentration of 0.1% for maximal yield of neomycin, whereas NaCl and the metals Mn and Cu were without any effect. High doses of Zn (0.23 μg/ml or above) caused destruction of neomycin after the fifth day of fermentation.
Title: Effects of Minerals on Neomycin Production by
Streptomyces fradiae
Description:
A study was made on the mineral requirements of
Streptomyces fradiae
strain 3535 for neomycin production.
It was observed that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production were 10.
8, 1.
0, and 0.
115 μg, respectively.
K
2
HPO
4
was required at a concentration of 0.
1% for maximal yield of neomycin, whereas NaCl and the metals Mn and Cu were without any effect.
High doses of Zn (0.
23 μg/ml or above) caused destruction of neomycin after the fifth day of fermentation.
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