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Longitudinal Assessment of Bile Duct Loss in Primary Biliary Cholangitis
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INTRODUCTION:
Bile duct involvement is a key finding of primary biliary cholangitis (PBC). The aim of this study was to evaluate baseline ductopenia and disease progression.
METHODS:
Retrospective longitudinal histological follow-up of treatment-naive patients with PBC.
RESULTS:
Eighty-three patients were included, with ductopenia correlated to fibrosis stage at baseline. The cumulative incidence of severe ductopenia remained stable after 5 years, whereas fibrosis continually increased over time. Baseline AST-to-Platelet Ratio Index and elevated alkaline phosphatase >2 times the normal with abnormal bilirubin were associated with ductopenia progression.
DISCUSSION:
Bile duct injury does not seem to follow the same course as fibrosis in PBC.
Ovid Technologies (Wolters Kluwer Health)
Title: Longitudinal Assessment of Bile Duct Loss in Primary Biliary Cholangitis
Description:
INTRODUCTION:
Bile duct involvement is a key finding of primary biliary cholangitis (PBC).
The aim of this study was to evaluate baseline ductopenia and disease progression.
METHODS:
Retrospective longitudinal histological follow-up of treatment-naive patients with PBC.
RESULTS:
Eighty-three patients were included, with ductopenia correlated to fibrosis stage at baseline.
The cumulative incidence of severe ductopenia remained stable after 5 years, whereas fibrosis continually increased over time.
Baseline AST-to-Platelet Ratio Index and elevated alkaline phosphatase >2 times the normal with abnormal bilirubin were associated with ductopenia progression.
DISCUSSION:
Bile duct injury does not seem to follow the same course as fibrosis in PBC.
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