GW24-e1252 Cardio-ankle vascular index and its possible related factors in hypertension subjects with mellitus diabetes

Objectives Arterial stiffness is one of the earliest detectable manifestations of adverse structural and functional change within the vessel wall. And it can be measured by cardio-ankle vascular index (CAVI). In the present study, we investigated the possible risk factors involving CAVI in hypertension subjects with mellitus diabetes (DM). Methods 223 male subjects (healthy (N = 122), hypertension (N = 73), DM (N = 15), hypertension + DM (N = 13), respectively) from health-care examination were recruited in our study. The VS-1000 was used to measure CAVI. Results CAVI was significantly higher in hypertension subjects with DM than in healthy group and hypertension group, respectively. CAVI was positively correlated with age, systolic blood pressure, pulse pressure, fasting plasma glucose, HbA1c in the entire study group (r = 0.636, 0.235, 0.240, 0.202, 0.333, all p < 0.05, respectively). Multiple regression analysis showed that age, HbA1c, body mass index, diastolic blood pressure were significant independent affecting factors of CAVI in all subjects (β = 0.528, p < 0.001; β = 0.184, p = 0.002; β = -0.210, p < 0.001; β = 0.178, p = 0.003; respectively). Conclusions CAVI was significantly higher in hypertension subjects with DM, and hyperglycemia might play an important role in the development of arteriosclerosis in hypertension subjects.