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Katanin
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Abstract
Katanin is a heterodimeric, ATP-dependent, microtubule-severing protein. Katanin utilizes ATP hydrolysis to generate internal breaks within microtubules and to disassemble microtubules to tubulin heterodimers without proteolysis or denaturation of tubulin.
Title: Katanin
Description:
Abstract
Katanin is a heterodimeric, ATP-dependent, microtubule-severing protein.
Katanin utilizes ATP hydrolysis to generate internal breaks within microtubules and to disassemble microtubules to tubulin heterodimers without proteolysis or denaturation of tubulin.
Related Results
Katanin‐mediated microtubule severing can be regulated by multiple mechanisms
Katanin‐mediated microtubule severing can be regulated by multiple mechanisms
AbstractMicrotubules are essential for a wide range of cellular processes that vary between cell types. Katanin is a microtubule‐severing protein that carries out an essential role...
Katanin inhibition prevents the redistribution of γ-tubulin at mitosis
Katanin inhibition prevents the redistribution of γ-tubulin at mitosis
Katanin is a microtubule-severing protein that is concentrated at mitotic spindle poles but katanin's function in the mitotic spindle has not been previously reported. Inhibition o...
Structural Basis for Katanin Self-Assembly
Structural Basis for Katanin Self-Assembly
SUMMARY
The reorganization of microtubules in mitosis, meiosis and development requires the microtubule-severing activity of katanin. Katanin is composed of a AAA A...
Katanin controls mitotic and meiotic spindle length
Katanin controls mitotic and meiotic spindle length
Accurate control of spindle length is a conserved feature of eukaryotic cell division. Lengthening of mitotic spindles contributes to chromosome segregation and cytokinesis during ...
Katanin-mediated severing generates microtubules during neurite outgrowth
Katanin-mediated severing generates microtubules during neurite outgrowth
Abstract
Neurons contain a polarized and staggered microtubule array that is important for supporting intracellular transport. How these microtubules are generated ...