Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
TAFENOQUINE FOR THE TREATMENT OF RECURRENT PLASMODIUM VIVAX MALARIA
View through CrossRef
Tafenoquine was used to treat Plasmodium vivax malaria cases who had previously failed treatment with chloroquine and primaquine. Chloroquine was followed by a loading dose of tafenoquine (200 mg base/day for 3 days) and 200 mg a week was given for 8 weeks. One of 27 treated patients relapsed after 6 months of observation. A standard course of chloroquine administered with 8 weeks of tafenoquine may be more effective than chloroquine with primaquine (22.5 mg/day for 14 days) in preventing additional P. vivax relapses. Larger studies are required to optimize the combination, but our findings suggest that an extended use of tafenoquine may be required to prevent relapses of primaquine-tolerant strains of P. vivax malaria.
American Society of Tropical Medicine and Hygiene
Title: TAFENOQUINE FOR THE TREATMENT OF RECURRENT PLASMODIUM VIVAX MALARIA
Description:
Tafenoquine was used to treat Plasmodium vivax malaria cases who had previously failed treatment with chloroquine and primaquine.
Chloroquine was followed by a loading dose of tafenoquine (200 mg base/day for 3 days) and 200 mg a week was given for 8 weeks.
One of 27 treated patients relapsed after 6 months of observation.
A standard course of chloroquine administered with 8 weeks of tafenoquine may be more effective than chloroquine with primaquine (22.
5 mg/day for 14 days) in preventing additional P.
vivax relapses.
Larger studies are required to optimize the combination, but our findings suggest that an extended use of tafenoquine may be required to prevent relapses of primaquine-tolerant strains of P.
vivax malaria.
Related Results
Population pharmacokinetics of the new antimalarial agent tafenoquine in Thai soldiers
Population pharmacokinetics of the new antimalarial agent tafenoquine in Thai soldiers
Aims  To describe the population pharmacokinetics of tafenoquine in healthy volunteers after receiving tafenoquine for malaria prophylaxis.Methods  The population consisted of 135 ...
Safety, pharmacokinetics, and potential neurological interactions of ivermectin, tafenoquine and chloroquine in Rhesus Macaques
Safety, pharmacokinetics, and potential neurological interactions of ivermectin, tafenoquine and chloroquine in Rhesus Macaques
Abstract
Ivermectin could be used for malaria control as treated persons are lethal to blood feeding
Anopheles
...
Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia
Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia
Abstract
Background
Cambodia has seen a marked reduction in the incidence of Plasmodium falciparum over the past decade without a corresponding decl...
Prevalence, Demographic Patterns, and Seasonal Distribution of Malaria in District Dera Ismail Khan, Pakistan
Prevalence, Demographic Patterns, and Seasonal Distribution of Malaria in District Dera Ismail Khan, Pakistan
Abstract
Malaria remains the most significant vector-borne disease worldwide, with over 200 million cases reported annually, causing approximatel...
Population Pharmacokinetics of Tafenoquine during Malaria Prophylaxis in Healthy Subjects
Population Pharmacokinetics of Tafenoquine during Malaria Prophylaxis in Healthy Subjects
ABSTRACT
The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking tafenoquine for malarial prophylaxis. The subjects (476 ma...
Musta mere ranniku eesti asunikud malaaria meelevallas
Musta mere ranniku eesti asunikud malaaria meelevallas
At the end of the 19th century, Estonian settlers encountered malaria in the Volga region and Siberia, but outbreaks with the most serious consequences hit Estonians in the Black S...
The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR
The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR
Abstract
Background
Trials to assess the efficacy of the radical cure of Plasmodium vivax malaria with 8-aminoquinolines require that most post-treatment relapses are identified, b...
Plasmodium vivax cerebral malaria in an adult patient in Sudan
Plasmodium vivax cerebral malaria in an adult patient in Sudan
Abstract
Background
Plasmodium vivax infection is rising in sub-Saharan Africa, where Plasmodium falciparum is responsible for more t...