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O2-Nanobubble of Iron-Porphyrin conjugated Polyaspartamide for Molecular Ultrasound Contrast Effect
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Abstract
Objective
This study aimed to prepare oxygen-nanobubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.
Results
We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created nanobubbles using 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). These nanobubbles trapped oxygen and retained it over a 2-hour period. The O2-nanobubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.
Conclusions
The innovative strategy for O2-nanobubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.
Springer Science and Business Media LLC
Title: O2-Nanobubble of Iron-Porphyrin conjugated Polyaspartamide for Molecular Ultrasound Contrast Effect
Description:
Abstract
Objective
This study aimed to prepare oxygen-nanobubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.
Results
We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created nanobubbles using 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC).
These nanobubbles trapped oxygen and retained it over a 2-hour period.
The O2-nanobubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.
Conclusions
The innovative strategy for O2-nanobubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.
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