Vascular Remodelling After Anti-vegf Treatment in Patients With Neovascular Age-related Macular Degeneration

Abstract Background:Age-related macular degeneration (AMD) is a progressive, degenerative disease of the central retina. AMD is subdivided into “dry” (atrophic), “wet” (exudative) and neovascular (nAMD) forms. In recent years, the concepts about nAMD changed with the development of optic coherence tomography – angiography (OCT-A) and intravitreal anti-VEGF treatment. The aim of this study is to define the morphologic type of the neovascular membrane (NVM) before treatment with OCT-A and to register vascular remodeling after treatment with anti-VEGF. We also analyzed the relationship between NVM and visual acuity.Methods:The study is retrospective and includes 119 patients, with newly diagnosed, treatment naïve nAMD. All the patients underwent full ophthalmic examination and also fluorescine angiography and optic coherence tomography – angiography (OCT-A). Results:Based on the collected data, we found repetitive regularities.Conclusion:The analysis of our results could be used as prognostic markers for the evolution of the disease and as a basis for new treatment strategies, depending on the naïve NVM morphologic type.