Repositioning randomly selected Drugs as Antidepressants by computational and Invivo methods

Abstract Drug repositioning is also known as drug repurposing, drug refilling. Drug repositioning is one of the most preferred field in current research. The drugs with different adverse effect and the drugs which are shelved can be used for the treatment of other diseases. Thus it helps in finding new therapeutic index for already existing drugs. The main advantage of this drug reposioning is it decreases the investment in drug discovery and optimization, and all the pharmacokinetics studies will be readily available as their profiles are already established. In recent times one of the most useful strategies for repositioning the drug of the therapeutic activity towards other new target is done by computational screening. The deeper knowledge about pathogenesis of depression helps us to develop or discover the new drug moieties through drug repositioning to treat the disease condition of depression. In this study we have selected randomly some available drugs and repurposed them as potent anti depressant agents using Insilico and Invivo studies.