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tRF-Pro-CGG suppresses cell proliferation and promotes apoptosis in pancreatic cancer
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Abstract
tRNA-derived RNA fragments (tRFS) are 14-38nt long non-coding single-stranded RNAs that play an important role in gene regulation. In this study, we investigated the expression of tRF-Pro-CGG in human pancreatic cancer (PC) and its role in the proliferation, cloning, metastasis, invasion and apoptosis of PC cell lines. We will investigate the expression levels of tRF-Pro-CGG in PC tissues and cells. In PC tissue, tRF-Pro-CGG RNA levels were lower than in normal tissue, and in PC cell lines, tRF-Pro-CGG RNA levels were lower. In PC cells, promotion of tRF-Pro-CGG inhibits cell proliferation, replication, migration, and invasion, and promotes apoptosis. CSF1 was also inhibited by tRF-Pro-CGG. tRF-Pro-CGG may be involved in the regulation of CSF1 and may become a new diagnostic marker or therapeutic target for PC.
Research Square Platform LLC
Title: tRF-Pro-CGG suppresses cell proliferation and promotes apoptosis in pancreatic cancer
Description:
Abstract
tRNA-derived RNA fragments (tRFS) are 14-38nt long non-coding single-stranded RNAs that play an important role in gene regulation.
In this study, we investigated the expression of tRF-Pro-CGG in human pancreatic cancer (PC) and its role in the proliferation, cloning, metastasis, invasion and apoptosis of PC cell lines.
We will investigate the expression levels of tRF-Pro-CGG in PC tissues and cells.
In PC tissue, tRF-Pro-CGG RNA levels were lower than in normal tissue, and in PC cell lines, tRF-Pro-CGG RNA levels were lower.
In PC cells, promotion of tRF-Pro-CGG inhibits cell proliferation, replication, migration, and invasion, and promotes apoptosis.
CSF1 was also inhibited by tRF-Pro-CGG.
tRF-Pro-CGG may be involved in the regulation of CSF1 and may become a new diagnostic marker or therapeutic target for PC.
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