Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Notch2-mediated plasticity between marginal zone and follicular B cells
View through CrossRef
AbstractFollicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a Notch2-dependent fate decision after splenic influx of immature transitional B cells. In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts. However, it is unclear whether FoB cells, which are in close contact with these DLL-1 expressing fibroblasts, can also differentiate to MZB cells if they receive a Notch2-signal. Here, we show induced Notch2IC-expression in FoB cells re-programs mature FoB cells into bona fide MZB cells as is evident from the surface phenotype, localization, immunological function and transcriptome of these cells. Furthermore, the lineage conversion from FoB to MZB cells occurs in immunocompetent wildtype mice. These findings demonstrate plasticity between mature FoB and MZB cells that can be driven by a singular signaling event, the activation of Notch2.
Springer Science and Business Media LLC
Title: Notch2-mediated plasticity between marginal zone and follicular B cells
Description:
AbstractFollicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a Notch2-dependent fate decision after splenic influx of immature transitional B cells.
In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts.
However, it is unclear whether FoB cells, which are in close contact with these DLL-1 expressing fibroblasts, can also differentiate to MZB cells if they receive a Notch2-signal.
Here, we show induced Notch2IC-expression in FoB cells re-programs mature FoB cells into bona fide MZB cells as is evident from the surface phenotype, localization, immunological function and transcriptome of these cells.
Furthermore, the lineage conversion from FoB to MZB cells occurs in immunocompetent wildtype mice.
These findings demonstrate plasticity between mature FoB and MZB cells that can be driven by a singular signaling event, the activation of Notch2.
Related Results
Complex Collision Tumors: A Systematic Review
Complex Collision Tumors: A Systematic Review
Abstract
Introduction: A collision tumor consists of two distinct neoplastic components located within the same organ, separated by stromal tissue, without histological intermixing...
Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol
Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol
Abstract
Taxanes are widely used in chemotherapy, but primary and acquired resistance limit the clinical efficacy. Studies have shown tumor interaction with macroph...
Unusual Metastasis from Follicular Thyroid Carcinoma: A Case Report and Literature Review
Unusual Metastasis from Follicular Thyroid Carcinoma: A Case Report and Literature Review
Abstract
Introduction
Follicular thyroid carcinoma (FTC) is a type of well-differentiated thyroid carcinoma. It has a poorer prognosis, is more metastatic, and has characteristics ...
Notch2 signaling guides B cells away from germinal centers towards marginal zone B cell and plasma cell differentiation
Notch2 signaling guides B cells away from germinal centers towards marginal zone B cell and plasma cell differentiation
Abstract
Notch2 signaling has a profound role in driving the development of Marginal Zone B (MZB) cells. We recently demonstrated that Follicular B (FoB) cells act ...
Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms
Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms
Background:
Published criteria to distinguish benign colloid nodules from follicular neoplasms emphasize only three interdependent features: size of follicles, amount of colloid, a...
Notch2 Deletion Compromises Epithelial Integrity and Enamel Formation in Rodent Incisors
Notch2 Deletion Compromises Epithelial Integrity and Enamel Formation in Rodent Incisors
The evolutionarily conserved Notch signalling pathway regulates the fate, proliferation and differentiation of cells in most developing organs, thus affecting their morphogenesis a...
CD5-Positive Marginal Zone Lymphoma: Clinicopathological Features And Survival Outcomes
CD5-Positive Marginal Zone Lymphoma: Clinicopathological Features And Survival Outcomes
Abstract
Background: CD5 expression in diffuse large B-cell lymphoma has a poor prognosis but the prognostic value of CD5 expression in marginal zone lymphoma is undefined....
Determine the Effect of Immunosuppressant on follicular regulatory T-cells in kidney transplant patients
Determine the Effect of Immunosuppressant on follicular regulatory T-cells in kidney transplant patients
Background: Over the last few years, there are two major problems identified during organ transplantation such as surgical restrictions and transplant rejections. Few of these obst...