Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Gold-Catalyzed Alkenylation and Arylation of Phosphorothioates
View through CrossRef
Reported herein is the gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides. The facile transmetalation between Ag-sulfur complex and Au(III) intermediate formed after oxidative addition is the key to the success of this transformation. This methodology operates under mild reaction conditions with catalyst loading as low as 1 mol%, thereby providing an efficient access to biologically active S-alkenyl and S-aryl phosphorothioates
Title: Gold-Catalyzed Alkenylation and Arylation of Phosphorothioates
Description:
Reported herein is the gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides.
The facile transmetalation between Ag-sulfur complex and Au(III) intermediate formed after oxidative addition is the key to the success of this transformation.
This methodology operates under mild reaction conditions with catalyst loading as low as 1 mol%, thereby providing an efficient access to biologically active S-alkenyl and S-aryl phosphorothioates.
Related Results
Comprehension of the α-Arylation of Nitroalkanes
Comprehension of the α-Arylation of Nitroalkanes
Background:
α-Aryl substituted nitroalkanes are important synthetic intermediates
for the preparation of pharmaceutical molecules, natural products, and functional
materials. Due t...
Challenging Atroposelective C–H Arylation
Challenging Atroposelective C–H Arylation
AbstractAtropisomeric molecules are privileged scaffolds, not only as ligands for asymmetric synthesis, but also as biologically active products and advanced materials. Although ve...
α‐Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
α‐Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
AbstractThis chapter presents the procedure for α‐arylation of cyclopentanones by palladium/enamine cooperative catalysis. The procedures inOrganic Synthesesare intended for use on...
Synthesis of phosphorothioates by photocatalytic sulfur transfer from thiosulfate
Synthesis of phosphorothioates by photocatalytic sulfur transfer from thiosulfate
With therapeutic oligonucleotides progressing from the treatment of rare genetic diseases to the medication of common disorders, the synthesis of modified oligonucleotides is gaini...
NATIVE GOLD OF UKRAINE, PREREQUISITES FOR THE CREATION OF ITS CRYSTALLOGENETIC DETERMINANT
NATIVE GOLD OF UKRAINE, PREREQUISITES FOR THE CREATION OF ITS CRYSTALLOGENETIC DETERMINANT
The main developments in the typomorphism of native gold from various depth and uneven-aged deposits are described briefly, and the basis for creating a native gold crystallogeneti...
Implications of Gold Trading for the Global Economy
Implications of Gold Trading for the Global Economy
One of the precious metals found in the earth’s crust, whose economic value dates back several centuries and remains relevant in our contemporary socio-economic settings, is gold. ...
Transition-Metal-Catalyzed Direct Arylation of Ammonia
Transition-Metal-Catalyzed Direct Arylation of Ammonia
AbstractIn the past few decades, transition-metal-catalyzed direct amination of aryl halides with ammonia has attracted significant attention from chemists because of its broad sub...
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
AbstractThe area of transition‐metal‐catalyzed direct arylation through cleavage of CH bonds has undergone rapid development in recent years, and is becoming an increasingly viabl...