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Naratuximab emtansine (IMGN529; Debo 1562) Drug Description
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Naratuximab emtansine, also known as IMGN529 and Debio 1562 is an antibody-drug conjugate (ADC) or immunoconjugate that consists of a humanized IgG1 antibody K7153A against the cell-surface antigen CD37, a member of the tetraspanin superfamily of cell surface antigens found on B-cell malignancies, that is covalently linked via the uncleavable, maleimide-derived thioether-based linker SMCC to the maytansinoid DM1, with potential pro-apoptotic and cytotoxic activities.
Title: Naratuximab emtansine (IMGN529; Debo 1562) Drug Description
Description:
Naratuximab emtansine, also known as IMGN529 and Debio 1562 is an antibody-drug conjugate (ADC) or immunoconjugate that consists of a humanized IgG1 antibody K7153A against the cell-surface antigen CD37, a member of the tetraspanin superfamily of cell surface antigens found on B-cell malignancies, that is covalently linked via the uncleavable, maleimide-derived thioether-based linker SMCC to the maytansinoid DM1, with potential pro-apoptotic and cytotoxic activities.
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