Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
In vitro ANTI-CANCER EFFECTS OF QUERCETIN ON TRIPLE NEGATIVE BREAST CANCER CELL LINE
View through CrossRef
Phytochemicals are widely being explored for their cancer preventive properties in today’s oncotherapy. Quercetin is a major constituent of various dietary products and its anti-cancer potential was explored on different cancer cell lines. The present study was conducted to find out the anti-proliferative effects of quercetin on human triple negative breast cancer cell line MDA-MB The anti-cancer potential of quercetin, nano-quercetin and doxorubicin at various concentrations were assessed by cellular cytotoxicity (MTT) assay. The IC50 values of quercetin, nano-quercetin and doxorubicin on MDA-MB 231 cell line were 394.8, 204.6 and 17.17 μM, respectively. In vitro anti-cancer effects of these drugs were manifested as apoptosis and cellular toxicity. The cytotoxicity was moderate in quercetin, remarkable in nano-quercetin and strong in doxorubicin treatments. The in vitro anti-cancer effect of quercetin was comparable with the standard drug doxorubicin. Considering the potential side effects of doxorubicin, the quercetin might be explored with further studies in the treatment of mammary tumours in animals and humans.
Title: In vitro ANTI-CANCER EFFECTS OF QUERCETIN ON TRIPLE NEGATIVE BREAST CANCER CELL LINE
Description:
Phytochemicals are widely being explored for their cancer preventive properties in today’s oncotherapy.
Quercetin is a major constituent of various dietary products and its anti-cancer potential was explored on different cancer cell lines.
The present study was conducted to find out the anti-proliferative effects of quercetin on human triple negative breast cancer cell line MDA-MB The anti-cancer potential of quercetin, nano-quercetin and doxorubicin at various concentrations were assessed by cellular cytotoxicity (MTT) assay.
The IC50 values of quercetin, nano-quercetin and doxorubicin on MDA-MB 231 cell line were 394.
8, 204.
6 and 17.
17 μM, respectively.
In vitro anti-cancer effects of these drugs were manifested as apoptosis and cellular toxicity.
The cytotoxicity was moderate in quercetin, remarkable in nano-quercetin and strong in doxorubicin treatments.
The in vitro anti-cancer effect of quercetin was comparable with the standard drug doxorubicin.
Considering the potential side effects of doxorubicin, the quercetin might be explored with further studies in the treatment of mammary tumours in animals and humans.
.
Related Results
Breast Carcinoma within Fibroadenoma: A Systematic Review
Breast Carcinoma within Fibroadenoma: A Systematic Review
Abstract
Introduction
Fibroadenoma is the most common benign breast lesion; however, it carries a potential risk of malignant transformation. This systematic review provides an ove...
Desmoid-Type Fibromatosis of The Breast: A Case Series
Desmoid-Type Fibromatosis of The Breast: A Case Series
Abstract
IntroductionDesmoid-type fibromatosis (DTF), also called aggressive fibromatosis, is a rare, benign, locally aggressive condition. Mammary DTF originates from fibroblasts ...
Predictors of False-Negative Axillary FNA Among Breast Cancer Patients: A Cross-Sectional Study
Predictors of False-Negative Axillary FNA Among Breast Cancer Patients: A Cross-Sectional Study
Abstract
Introduction
Fine-needle aspiration (FNA) is commonly used to investigate lymphadenopathy of suspected metastatic origin. The current study aims to find the association be...
Abstract OI-1: OI-1 Decoding breast cancer predisposition genes
Abstract OI-1: OI-1 Decoding breast cancer predisposition genes
Abstract
Women with one or more first-degree female relatives with a history of breast cancer have a two-fold increased risk of developing breast cancer. This risk i...
Spanish Breast Cancer Research Group (GEICAM)
Spanish Breast Cancer Research Group (GEICAM)
This section provides current contact details and a summary of recent or ongoing clinical trials being coordinated by Spanish Breast Cancer Research Group (GEICAM). Clinical trials...
International Breast Cancer Study Group (IBCSG)
International Breast Cancer Study Group (IBCSG)
This section provides current contact details and a summary of recent or ongoing clinical trials being coordinated by International Breast Cancer Study Group (IBCSG). Clinical tria...
The impact of preoperative breast magnetic resonance imaging (MRI) on surgical decision-making in young patients with breast cancer.
The impact of preoperative breast magnetic resonance imaging (MRI) on surgical decision-making in young patients with breast cancer.
Abstract
Abstract #4012
Recent data suggests that breast MRI is a more sensitive diagnostic test for detecting invasive breast cancer than mammography...
Abstract 1416: Synergistic cytotoxicity of metformin cotreatment with paclitaxel or carboplatin in triple negative breast cancer cell lines
Abstract 1416: Synergistic cytotoxicity of metformin cotreatment with paclitaxel or carboplatin in triple negative breast cancer cell lines
Abstract
Metformin is an oral antidiabetic drug with a putative antineoplastic effect in breast cancer; however, its efficacy in clinical trials has been mixed. Trip...