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Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction
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Abstract:
In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal
screening tool, it has gained recognition for its sensitivity and specificity in the detection of common
aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following
assisted reproductive technology (ART) in the light of current evidence and recommendations. It also
deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies,
with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded
as the Achilles’ heel of most pre-natal screening platforms. Future directions for exploration towards
improving the performance and extending the scope of NIPT are also addressed.
Bentham Science Publishers Ltd.
Title: Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction
Description:
Abstract:
In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal
screening tool, it has gained recognition for its sensitivity and specificity in the detection of common
aneuploidies.
This review mainly focuses on the emerging role of NIPT in pregnancies following
assisted reproductive technology (ART) in the light of current evidence and recommendations.
It also
deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies,
with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded
as the Achilles’ heel of most pre-natal screening platforms.
Future directions for exploration towards
improving the performance and extending the scope of NIPT are also addressed.
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