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Synthesis of fluoroalkyl and fluoroaryl substituted hexahydropyrimidines
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The data on the synthesis of fluoroalkyl and fluoroaryl substituted hexahydropyrimidine derivatives from the moment of their first mention are systematized. Predominantly one-pot multicomponent synthesis methods, including catalytic ones, are considered. The effect of the nature of the catalyst, starting reagents, and synthesis conditions on the yield and composition of the resulting products is discussed, and the biological activity of some derivatives is also shown.
Title: Synthesis of fluoroalkyl and fluoroaryl substituted hexahydropyrimidines
Description:
The data on the synthesis of fluoroalkyl and fluoroaryl substituted hexahydropyrimidine derivatives from the moment of their first mention are systematized.
Predominantly one-pot multicomponent synthesis methods, including catalytic ones, are considered.
The effect of the nature of the catalyst, starting reagents, and synthesis conditions on the yield and composition of the resulting products is discussed, and the biological activity of some derivatives is also shown.
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