Synthesis and Antibacterial Evaluation of Pyrazole Integrated Oxadiazole Derivatives

Pyrazole, Pyridine, and oxadiazole are important scaffolds because of having medicinal applications like anticonvulsant, hypoglycemia, molluscicidal, stimulant, and anticancer, etc. At present, to achieve a highly potent molecule we have synthesized a novel series of pyrazole bearing 1,3,4-oxadiazole heterocycles 4a–o (1-(3,5-substituted-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)ethan-1-one) were and characterized by mass spectroscopy, 1H and 13C NMR spectroscopy, and Infrared spectroscopy. All synthesized compounds were evaluated against gram-positive and gram-negative bacterial strains.