LDCT Screening Results among Health Check-ups Population

Abstract Objective To compare the LDCT screening results between eligible and ineligible screening candidates in preventive health check-ups population. Study Design and Setting Using a real-world LDCT screening results among people who took yearly health check-up in health management center of West China Hospital between 2006 and 2017. Objects were classified according to the China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version) eligibility criteria. Descriptive analysis were performed between eligible and ineligible screening candidates. Results The proportion of ineligible screening candidates was 64.13% (10259), and among them there were 4005(39.04%) subjects with positive screenings, 80 cases had a surgical lung biopsy. Pathology results from lung biopsy revealed 69 cancers (true-positive) and 11 benign results (false-positive). The difference of the false-positive biopsy rate between ineligible screening candidates (13.75%) and eligible screening candidates(15.00%) was no statistically significant (P>0.05). Further, in ineligible screening candidates, the proportion of current smokers was higher among males compared to females (53.85% vs. 4.88%, P<0.05). Of the 69 lung cancer patients detected in ineligible screening candidates, lung adenocarcinoma accounts for a high proportion of lung cancers both in male (75.00%) and female (85.00%). Conclusion The proportion of ineligible screening candidates was high in health check-ups population.