Medical Management of Pulmonary Hypertension: Calcium Channel Blockers Vs Sildenafil A Systematic Review

Background: Pulmonary hypertension can be defined as incompatibility in blood pressure level into vessels and right side of heart is affected severely through this. As a result, heart failure among patients is common and reduction of blood flow affects negatively over respiratory rate. Calcium channel blockers such as Amlodipine, Nicardipine, Felodipin are potential to slow down blood pressure and accumulation of calcium ions are decreased in vessel wall. In addition, Sildenafil is an active Viagra component that also helps to regulate thickness of blood vessels for controlling pressure. This study mainly focuses on comparing medical management strategy of pulmonary hypertension by using Calcium channel blockers and Sildenafil. Methods: This study is actually a systemic review to analyse the impact of Calcium channel blockers and Sildenafil on patients suffering from pulmonary hypertension. Original full research articles are selected for literature review and 63 patients are detected for easy comparison of drug usage and facilities. Both of the drugs have been applied with 0.3 mg/kg dose for each of the sample population to understand hypertension crisis. All the demographic, postoperative and preoperative variables have been discussed promptly for acquiring proper knowledge. Results: The result has shown that Calcium channel blockers are better to treat pulmonary hypertension than Sildenafil by delivering no side effects on patients. On the other hand, therapeutic value of Calcium channel blockers is greater than Sildenafil and it helps to act at a limit for blood pressure lowering. In addition, a potential correlation between heart failure, pulmonary hypertension and medical management has been determined. Conclusion and discussion: This study concludes that pulmonary hypertension crisis has been reduced potentially by applying Calcium channel blockers as well as Sildenafil. However, lack of accumulation of calcium in blood vessel is a more suitable approach than applying strong Viagra component named Sildenafil.