Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Temporal and spatial distribution of histone acetylation in mouse molar development
View through CrossRef
Histone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood. Using the mouse molar as a model, we mapped the distribution patterns of histone H3 and H4, as well as their corresponding acetylation sites during tooth formation in order to unveil the connection between histone acetylation modification and tooth development. Moreover, key histone acetyltransferases and histone deacetylases were detected in both epithelial and mesenchymal cells during tooth development by scRNA-seq and immunohistochemistry. These results suggest that histone acetylation modification functions as an important mechanism in tooth development at different stages.
Title: Temporal and spatial distribution of histone acetylation in mouse molar development
Description:
Histone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis.
However, the role of histone acetylation in tooth development is poorly understood.
Using the mouse molar as a model, we mapped the distribution patterns of histone H3 and H4, as well as their corresponding acetylation sites during tooth formation in order to unveil the connection between histone acetylation modification and tooth development.
Moreover, key histone acetyltransferases and histone deacetylases were detected in both epithelial and mesenchymal cells during tooth development by scRNA-seq and immunohistochemistry.
These results suggest that histone acetylation modification functions as an important mechanism in tooth development at different stages.
Related Results
Progress of Acetylation Modification in Plants
Progress of Acetylation Modification in Plants
Protein acetylation, a conserved post-translational modification, is collaboratively catalyzed by acetyltransferases and deacetylases and is widespread in plants. This study review...
Cell-cycle-dependent repression of histone gene transcription by histone H4
Cell-cycle-dependent repression of histone gene transcription by histone H4
Abstract
In all eukaryotes DNA replication is coupled to histone synthesis to coordinate chromatin packaging of the genome. Canonical histone gen...
Exploring Histone Acetylation in Ischemic Stroke: The Role of CREBBP and CKAP4 as Key Biomarkers
Exploring Histone Acetylation in Ischemic Stroke: The Role of CREBBP and CKAP4 as Key Biomarkers
Abstract
Background
Ischemic stroke (IS) is a serious cerebrovascular disease. Excessive acetylated protein levels are linked to neuronal resistance to ischemia, making hi...
Flame retardant tetrabromobisphenol A (TBBPA) disrupts histone acetylation during zebrafish maternal-to-zygotic transition
Flame retardant tetrabromobisphenol A (TBBPA) disrupts histone acetylation during zebrafish maternal-to-zygotic transition
ABSTRACT
3,3’,5.5’-Tetrabromobisphenol A (TBBPA) is a widely used brominated flame-retardant utilized in the production of electronic devices and plastic paints. Th...
Towards an understanding of the biological function of histone acetylation
Towards an understanding of the biological function of histone acetylation
A model is presented which explains the biological function of posttranslational acetylation of core histones in chromatin. Along the lines of this model histone acetylation serves...
Cytosolic Histone H1.2 Releasing under Different Apoptotic Stimuli in Chronic Lymphocytic Leukemia (CLL).
Cytosolic Histone H1.2 Releasing under Different Apoptotic Stimuli in Chronic Lymphocytic Leukemia (CLL).
Abstract
Recently, it has been shown that nuclear histone H1.2 is released into cytoplasm when apoptosis is induced by DNA double-strand breaks (DSB’s), this process...
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
ABSTRACT
Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in...
Rabbit Antibodies Induced by Calf Thymus Histone-Serum Albumin Complexes
Rabbit Antibodies Induced by Calf Thymus Histone-Serum Albumin Complexes
Summary
Antibodies that react in C′ fixation with calf thymus histone determinants have been produced in two rabbits by immunization with whole histone coupled to hu...