Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Presence and Interactions of Entamoeba histolytica Lectin and p53 Protein in Colorectal Cancer
View through CrossRef
Background: We aimed to analyze the presence of Entamoeba histolytica lectin light chain antigen and p53 protein in colorectal cancer biopsies to uncover potential antigenic interactions between them.
Methods: Overall, 150 colorectal cancer biopsy samples were subjected to examination for the specific E. histolytica antigen and p53 protein through the application of the immunohistochemical technique. To augment diagnostic precision, the western blotting method was employed and its results were compared with those obtained from immunohistochemistry (IHC).
Results: Among the 150 colorectal cancer biopsy samples examined, 100 cases tested positive for the p53 protein, while 19 cases exhibited positivity for the E. histolytica light chain lectin antigen. Notably, only 14 cases demonstrated a positive presence for both the p53 protein and the E. histolytica protozoan.
Conclusion: Entamoeba histolytica, a leading cause of parasitic infections, raises questions about its potential link to colorectal cancer, specifically in connection with the p53 protein. The findings presented in this investigation signal the need for further research to comprehensively understand the implications of E. histolytica in colorectal cancer diagnosis and treatment strategies.
Title: Presence and Interactions of Entamoeba histolytica Lectin and p53 Protein in Colorectal Cancer
Description:
Background: We aimed to analyze the presence of Entamoeba histolytica lectin light chain antigen and p53 protein in colorectal cancer biopsies to uncover potential antigenic interactions between them.
Methods: Overall, 150 colorectal cancer biopsy samples were subjected to examination for the specific E.
histolytica antigen and p53 protein through the application of the immunohistochemical technique.
To augment diagnostic precision, the western blotting method was employed and its results were compared with those obtained from immunohistochemistry (IHC).
Results: Among the 150 colorectal cancer biopsy samples examined, 100 cases tested positive for the p53 protein, while 19 cases exhibited positivity for the E.
histolytica light chain lectin antigen.
Notably, only 14 cases demonstrated a positive presence for both the p53 protein and the E.
histolytica protozoan.
Conclusion: Entamoeba histolytica, a leading cause of parasitic infections, raises questions about its potential link to colorectal cancer, specifically in connection with the p53 protein.
The findings presented in this investigation signal the need for further research to comprehensively understand the implications of E.
histolytica in colorectal cancer diagnosis and treatment strategies.
Related Results
Molecular identification of EhCRT gene Calreticulin isolated from children infected with Entamoeba histolytica
Molecular identification of EhCRT gene Calreticulin isolated from children infected with Entamoeba histolytica
Objective: To detect the gene of entamoeba histolytica by polymerase chain reaction and investigate theexpression of immunogene entamoeba histolytica calreticulin in stool samples ...
High P53 Protein Expression Level Independent of Mutational Status Is An Adverse Prognostic Factor for Survival in Acute Myeloid Leukemia
High P53 Protein Expression Level Independent of Mutational Status Is An Adverse Prognostic Factor for Survival in Acute Myeloid Leukemia
Abstract
Abstract 1490
Background:
The tumor suppressor p53 is frequently mutated in human cancer, including acut...
Abstract 3500: Mitochondrially targeted p53 domains as a stand alone or adjunct to paclitaxel for the treatment of ovarian cancer
Abstract 3500: Mitochondrially targeted p53 domains as a stand alone or adjunct to paclitaxel for the treatment of ovarian cancer
Abstract
Although the main function of p53 is a nuclear transcription factor that has important roles in cell cycle arrest, DNA repair, and apoptosis, p53 can direct...
Abstract 599: Id4 acts as a tumor suppressor by inducing apoptosis and senescence in p53-dependent manner
Abstract 599: Id4 acts as a tumor suppressor by inducing apoptosis and senescence in p53-dependent manner
Abstract
The physiological mechanisms that can restore biological activity of mutant p53 is an area of high interest given that mutant p53 expression is observed in ...
Jun Dimerization Protein 2 (JDP2) Increases p53 Transactivation by Decreasing MDM2
Jun Dimerization Protein 2 (JDP2) Increases p53 Transactivation by Decreasing MDM2
The AP-1 protein complex primarily consists of several proteins from the c-Fos, c-Jun, activating transcription factor (ATF), and Jun dimerization protein (JDP) families. JDP2 has ...
Abstract A13: Applied the proteomics characteristics to detect the inherited colorectal adenomas
Abstract A13: Applied the proteomics characteristics to detect the inherited colorectal adenomas
Abstract
Introduction: Current study found that about one-third of the incidence of colorectal cancer have genetic related. Hereditary nonpolyposis colorectal cancer...
Abstract 1716: A small molecule corrector for p53 mutants found in cancer
Abstract 1716: A small molecule corrector for p53 mutants found in cancer
Abstract
p53 is the main tumor suppressor protein in vertebrates and the most frequently mutated gene in human cancers. The majority of p53 mutations are missense mu...
The effect of Entamoeba histolytica Lectin Antigen and MicroRNA-643 on the development of microsatellite instability (MSI) in Colorectal Adenocarcinoma
The effect of Entamoeba histolytica Lectin Antigen and MicroRNA-643 on the development of microsatellite instability (MSI) in Colorectal Adenocarcinoma
Abstract
Globally, Entamoeba histolytica remains a leading cause of death. The impact of protozoa as environmental factors in microsatellite instability (MSI) remains large...