Synthesis and study biological activity of some 1,8- Naphthyriane Derivatives

The compound 4-carboxy -2-phenyl-1,8- naphthyridine was synthesized from pyruvic acid, 2-Aminopyridine and Benzaldchyde (I).4-Hydrocynoamine-2-phenyl-1,8- Naphthyridine synthhesized from 4-Carboxy-2-phenyl-1.8-naphthyridine and phosphor penta chloride anhydrous in carbon tetra chloride, the resultant derivative was then separated by crushed ice and filtrated, the solid acid chloride thus obtained was used for further reaction. to the solid which was form was added hydrazine hydrate (II).4(p-phenyl dimethyl aminc) -hydrazine)-1,8-Naphthyridine (III) was synthesized from refluxed equimolar quantities of (II) with p.Dimethylamino- Benzaldephyde in ethanol. The purity of the synthesized compounds were established through R spectroscopy. and the purity were confirmed by TLC. the physical properties such as melting point and percentage were determined. The antibacterial activity of synthesized compounds (I, II, III) were tested by using agar diffusion method against some bacterial species, the compounds exhibit highest antibacterial activity specially compound III, also the Minimal inhibitory concentration (MIC) of tested compounds  (I, II, III) were determined, the results showed that MIC values ranged (5-20) μg/ml for all bacterial species in this study,  Pseudomsonas aerogenosa, Escherichia coli,Proteus sp, Staphylococcus aureus, Klebsiella sp., Sallmonella sp. ,Streptococcus sp.