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Vaccine Preventable Illness After Blinatumomab Therapy: A Case Report
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The use of blinatumomab for treatment of B-cell acute lymphoblastic
leukemia (ALL) has demonstrated efficacy in adults, which has resulted
in wider use within the pediatric population. While the side effects
have been fairly well-established in the adult population, they have not
been well studied in pediatric patients. We describe a case of a
3-year-old fully vaccinated male with high throughput sequencing minimal
residual disease positive B-Cell ALL after induction therapy treated
with blinatumomab who subsequently experienced two separate episodes of
Streptococcus pneumoniae bacteremia. Our patient’s clinical
course raises the question whether blinatumomab increases the risk of
vaccine-preventable illnesses in pediatric patients with leukemia.
Title: Vaccine Preventable Illness After Blinatumomab Therapy: A Case Report
Description:
The use of blinatumomab for treatment of B-cell acute lymphoblastic
leukemia (ALL) has demonstrated efficacy in adults, which has resulted
in wider use within the pediatric population.
While the side effects
have been fairly well-established in the adult population, they have not
been well studied in pediatric patients.
We describe a case of a
3-year-old fully vaccinated male with high throughput sequencing minimal
residual disease positive B-Cell ALL after induction therapy treated
with blinatumomab who subsequently experienced two separate episodes of
Streptococcus pneumoniae bacteremia.
Our patient’s clinical
course raises the question whether blinatumomab increases the risk of
vaccine-preventable illnesses in pediatric patients with leukemia.
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