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High Homogeneity of the Yersinia pestis Fatty Acid Composition
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ABSTRACT
The cellular fatty acid compositions of 29 strains of
Yersinia pestis
representing the global diversity of this species have been analyzed by gas-liquid chromatography to investigate the extent of fatty acid polymorphism in this microorganism. After culture standardization, all
Y. pestis
strains studied displayed some major fatty acids, namely, the 12:0, 14:0, 3-OH-14:0, 16:0, 16:1ω9cis, 17:0-cyc, and 18:1ω9trans compounds. The fatty acid composition of the various isolates studied was extremely homogeneous (average Bousfield's coefficient, 0.94) and the subtle variations observed did not correlate with epidemiological and genetic characteristics of the strains.
Y. pestis
major fatty acid compounds were analogous to those found in other
Yersinia
species. However, when the ratios for the 12:0/16:0 and 14:0/16:0 fatty acids were plotted together, the genus
Yersinia
could be separated into three clusters corresponding to (i) nonpathogenic strains and species of
Yersinia
, (ii) pathogenic
Yersinia enterocolitica
isolates, and (iii)
Yersinia pseudotuberculosis
and
Y. pestis
strains. The grouping of the two latter species into the same cluster was also demonstrated by their high Bousfield's coefficients (average, 0.89). Therefore, our results indicate that the fatty acid composition of
Y. pestis
is highly homogeneous and very close to that of
Y. pseudotuberculosis
.
American Society for Microbiology
Title: High Homogeneity of the
Yersinia pestis
Fatty Acid Composition
Description:
ABSTRACT
The cellular fatty acid compositions of 29 strains of
Yersinia pestis
representing the global diversity of this species have been analyzed by gas-liquid chromatography to investigate the extent of fatty acid polymorphism in this microorganism.
After culture standardization, all
Y.
pestis
strains studied displayed some major fatty acids, namely, the 12:0, 14:0, 3-OH-14:0, 16:0, 16:1ω9cis, 17:0-cyc, and 18:1ω9trans compounds.
The fatty acid composition of the various isolates studied was extremely homogeneous (average Bousfield's coefficient, 0.
94) and the subtle variations observed did not correlate with epidemiological and genetic characteristics of the strains.
Y.
pestis
major fatty acid compounds were analogous to those found in other
Yersinia
species.
However, when the ratios for the 12:0/16:0 and 14:0/16:0 fatty acids were plotted together, the genus
Yersinia
could be separated into three clusters corresponding to (i) nonpathogenic strains and species of
Yersinia
, (ii) pathogenic
Yersinia enterocolitica
isolates, and (iii)
Yersinia pseudotuberculosis
and
Y.
pestis
strains.
The grouping of the two latter species into the same cluster was also demonstrated by their high Bousfield's coefficients (average, 0.
89).
Therefore, our results indicate that the fatty acid composition of
Y.
pestis
is highly homogeneous and very close to that of
Y.
pseudotuberculosis
.
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