Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery
View through CrossRef
AbstractQuercetin, a natural flavonoid with antioxidant, anti‐inflammatory, and anticancer properties, faces limitations in clinical application due to its poor solubility and bioavailability. This study presents a novel delivery system utilizing a combination of polyoxyethylene (100) stearyl ether and folic acid to enhance quercetin's effectiveness. We developed folate‐conjugated polyoxyethylene (100) stearyl ether‐coated liposomes (FA‐Brij‐LPs) to leverage the unique properties of polyoxyethylene (100) stearyl ether in conjunction with folic acid for targeted delivery. The FA‐Brij‐LPs were prepared using the thin‐film hydration method and characterized for their physicochemical properties, including size, zeta potential, and drug loading capacity. The optimized FA‐Brij‐LPs exhibited a mean particle size of 147.57 nm, a zeta potential of 32.20 mV, and a drug loading capacity of 9.33 %. In vitro studies demonstrated sustained quercetin release and significantly enhanced cellular uptake compared to free quercetin. The Resazurin cell viability assay further revealed superior anticancer efficacy of FA‐Brij‐LPs. This innovative approach underscores the effectiveness of combining polyoxyethylene (100) stearyl ether with folic acid in enhancing quercetin delivery and its potential applications in cancer therapy.
Title: Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery
Description:
AbstractQuercetin, a natural flavonoid with antioxidant, anti‐inflammatory, and anticancer properties, faces limitations in clinical application due to its poor solubility and bioavailability.
This study presents a novel delivery system utilizing a combination of polyoxyethylene (100) stearyl ether and folic acid to enhance quercetin's effectiveness.
We developed folate‐conjugated polyoxyethylene (100) stearyl ether‐coated liposomes (FA‐Brij‐LPs) to leverage the unique properties of polyoxyethylene (100) stearyl ether in conjunction with folic acid for targeted delivery.
The FA‐Brij‐LPs were prepared using the thin‐film hydration method and characterized for their physicochemical properties, including size, zeta potential, and drug loading capacity.
The optimized FA‐Brij‐LPs exhibited a mean particle size of 147.
57 nm, a zeta potential of 32.
20 mV, and a drug loading capacity of 9.
33 %.
In vitro studies demonstrated sustained quercetin release and significantly enhanced cellular uptake compared to free quercetin.
The Resazurin cell viability assay further revealed superior anticancer efficacy of FA‐Brij‐LPs.
This innovative approach underscores the effectiveness of combining polyoxyethylene (100) stearyl ether with folic acid in enhancing quercetin delivery and its potential applications in cancer therapy.
Related Results
Coating Processes of Pharmaceutical Applicability: A Glimpse
Coating Processes of Pharmaceutical Applicability: A Glimpse
Presentation of manuscript is aiming to furnish glimpse on coating processes. Coating is process of snugly covering substrate surface with coating materials (CoM). In due course co...
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
BACKGROUND
As of July 2020, a Web of Science search of “machine learning (ML)” nested within the search of “pharmacokinetics or pharmacodynamics” yielded over 100...
Wound Healing Effects of Liposomal Nanocurcumin and PL Pro Nanocurcumin on Thermal Burn and Skin Ulcer
Wound Healing Effects of Liposomal Nanocurcumin and PL Pro Nanocurcumin on Thermal Burn and Skin Ulcer
Background
Burn injuries and skin ulcers are important health problems resulting in physical and psychological scars and chronic disabilities. This study investigated the wo...
The Promise of Exosomes as Drug Delivery Systems
The Promise of Exosomes as Drug Delivery Systems
Exosomes are small extracellular vesicles that play a role in cell-to-cell communication by transferring bioactive molecules such as proteins, nucleic acids, and lipids between cel...
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
Background:
Despite improvements in drug therapy and treatment of lumbar spinal disorders, dependence on opioid medication for postoperative pain control remains a conc...
Liposomal bupivacaine versus ropivacaine perianal infiltration for postoperative analgesia of haemorrhoidectomy: a multicentre, randomised controlled trial
Liposomal bupivacaine versus ropivacaine perianal infiltration for postoperative analgesia of haemorrhoidectomy: a multicentre, randomised controlled trial
Objectives
To evaluate whether liposomal bupivacaine provides superior postoperative analgesia compared with ropivacaine following haemorrhoidectomy, reduces th...
NANOMEDICINE IN ANTICANCER THERAPY
NANOMEDICINE IN ANTICANCER THERAPY
The use of liposomal nanoparticles as a drug delivery system today is a promising area of modern nanopharmacology, in particular in the development of antitumor drugs. Liposomal fo...
Controlled Drug Delivery Systems
Controlled Drug Delivery Systems
In most forms of drug delivery, spatial localization and duration of drug concentration are constrained by organ physiology and metabolism. For example, drugs administered orally w...