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Dysfunction of calcium regulating system in comorbidity of peptic ulcer disease and osteoporosis and its correction
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The comorbidity of various diseases requires the use of drugs that affect common etiological and pathogenetic aspects, which reduces polypharmacy and the risk of side-effect.Purpose of the study.Find out the state of calcium regulating system, calcium-phosphorus balance in the comorbidity of ulcer disease (UD) with osteoporosis (OP), and the effect of their shifts on the acid secretion and regional microcirculation. To determine the effectiveness of bisphosphonates in the complex treatment of these pathologies.Materials and methods.We examined 77 people with recurrent UD, 10 of whom revealed its comorbidity with OP. All patients underwent clinical and endoscopic studies, pH-metry, X-ray densitometry. The levels of parathyroid hormone, calcitonin, calcium and phosphorus in the blood were studiedResults.Recurrent of ulcer was characterized by a increase in para- thyroid hormone and calcium, a decrease in blood phosphorus. These changes were more pronounced in patients with a comorbidity of UD with OP and were accompanied by an increase in acid secretion and regional microcirculation. The use of etidronic acid in the treatment UD was characterized by a positive clinical result, normalization of secretion and regional microcirculation.Conclusion.The comorbidity of UD with OP is accompanied by functional changes in calcium regulating system. Correction of these changes with the use of bisphosphonates in the treatment of relapse of ulcer demonstrates clinical efficacy.
Title: Dysfunction of calcium regulating system in comorbidity of peptic ulcer disease and osteoporosis and its correction
Description:
The comorbidity of various diseases requires the use of drugs that affect common etiological and pathogenetic aspects, which reduces polypharmacy and the risk of side-effect.
Purpose of the study.
Find out the state of calcium regulating system, calcium-phosphorus balance in the comorbidity of ulcer disease (UD) with osteoporosis (OP), and the effect of their shifts on the acid secretion and regional microcirculation.
To determine the effectiveness of bisphosphonates in the complex treatment of these pathologies.
Materials and methods.
We examined 77 people with recurrent UD, 10 of whom revealed its comorbidity with OP.
All patients underwent clinical and endoscopic studies, pH-metry, X-ray densitometry.
The levels of parathyroid hormone, calcitonin, calcium and phosphorus in the blood were studiedResults.
Recurrent of ulcer was characterized by a increase in para- thyroid hormone and calcium, a decrease in blood phosphorus.
These changes were more pronounced in patients with a comorbidity of UD with OP and were accompanied by an increase in acid secretion and regional microcirculation.
The use of etidronic acid in the treatment UD was characterized by a positive clinical result, normalization of secretion and regional microcirculation.
Conclusion.
The comorbidity of UD with OP is accompanied by functional changes in calcium regulating system.
Correction of these changes with the use of bisphosphonates in the treatment of relapse of ulcer demonstrates clinical efficacy.
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