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Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association
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The CD8α cytoplasmic domain associates with p56
lck
, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8α-Lck association in T cell development was tested with transgenic mice generated to express a CD8α molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8α with Lck. The CD8α mutant was analyzed in a CD8
-/-
background and in the context of the transgenic 2C T cell receptor. The development and function of CD8
+
T cells in these mice were apparently normal. Thus, CD8α-Lck association is not necessary for positive selection, negative selection, or CD8-dependent cytotoxic function.
American Association for the Advancement of Science (AAAS)
Title: Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association
Description:
The CD8α cytoplasmic domain associates with p56
lck
, a nonreceptor protein-tyrosine kinase.
The biological relevance of CD8α-Lck association in T cell development was tested with transgenic mice generated to express a CD8α molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8α with Lck.
The CD8α mutant was analyzed in a CD8
-/-
background and in the context of the transgenic 2C T cell receptor.
The development and function of CD8
+
T cells in these mice were apparently normal.
Thus, CD8α-Lck association is not necessary for positive selection, negative selection, or CD8-dependent cytotoxic function.
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