Effect of Bilateral Oophorectomy and Natural Menopause on Bone Mineral Density

The objective of this study was to assess the effect of bilateral oophorectomy on bone mineral density in comparison with natural menopause. Bone mineral density (BMD) is  measured with dual energy X-ray DXA of lumber spine and femoral neck in 133 women, aged ranged (45 -70 years). Two surgical groups consist of 100 women either after or before, surgical after menopause SAM women with mean age (66.55 ± 1.11 years), menopause duration mean (15.88 ± 1.19 years) and body mass index BMI mean (32.09 ± 1.37 Kg /m2). Women who underwent surgery before menopause SBM the mean age (57.18 ± 0.84 years), (13.31 ± 0.83 years) the mean of menopause duration and (32.26 ± 0.7 Kg /m2) the mean of body mass index BMI. The natural menopause NM include 33 women mean age (56.45 ± 0.93 years) with (6.24 ± 0.81 years) duration of menopause and (33.49 ± 1.08 Kg /m2) BMI. The mean of BMD and T-score in lumber spine L1-L4 in SAM group was (0.84 ± 0.03 gr/cm2 and -2.32 ± 0.25) respectively, in the SBM group (BMD = 0.82 ± 0.01 gr/cm2 and T-score -2.46 ± 0.12) comparing to natural menopause group NM (BMD = 1.16 ± 0.03 gr /cm2 and T-score 0.31 ± 0.23). The mean of BMD measured for femoral neck in SAM (0.72± 0.03 gr /cm2 and T-score = - 1.54 ± 0.2), in SBM (BMD = 0.81 ± 0.81 gr/cm2 and T-score = - 0.86 ± 0.12), in NM (BMD = 0.93 ± 0.03 gr/cm2 and T-score = 0.3 6 ± 0.03). Bilateral oophorectomy associated with decrease in BMD, in addition age and duration of menopause are important factors affected on BMD.